Principal Scientist, Target Binding Job at Generate Biomedicines, Somerville, MA

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  • Generate Biomedicines
  • Somerville, MA

Job Description

Generate Biomedicines seeks a Principal Scientist to lead target binding efforts within the Protein Analytics & Biophysics department. This role combines technical expertise in biophysical assay development, technology innovation, cross-functional program leadership, and direct management of junior scientists across multiple biotherapeutic discovery programs.

Responsibilities

  • Lead target binding strategy and execution across multiple biotherapeutic programs
  • Design, develop, and optimize quantitative protein-protein interaction and cell-binding assays
  • Develop approaches to measure affinity, kinetics, stoichiometry, and complex binding mechanisms
  • Advance the target binding platform by evaluating and implementing emerging technologies
  • Establish standards for assay quality, instrumentation, data processing, and reproducibility

Requirements

  • Ph.D. in biochemistry, biophysics, analytical chemistry, protein science, or related discipline
  • 8+ years of relevant industry experience in protein-protein interaction assay development
  • Deep expertise with SPR, BLI, KinExA, and cell-binding measurement technologies
  • Demonstrated success characterizing complex protein interactions and developing novel measurement methods
  • Experience leading scientific strategy across cross-functional programs
  • Proven track record managing and mentoring scientists or research associates
  • Strong quantitative, statistical, and problem-solving skills

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